Acceleration of thiol additive-free native chemical ligation by intramolecular S → S acyl transfer.
نویسندگان
چکیده
Peptide-mercaptopropionylcysteine (MPA-Cys) thioesters show a surprisingly high reactivity in native chemical ligation (NCL) and allow thiol-additive free reactions. This facilitates sequential NCL reactions and ligation-desulfurization reactions in one-pot formats. The synthetic utility is demonstrated by the synthesis of a SH3 domain.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 35 شماره
صفحات -
تاریخ انتشار 2015